Captions provided by CCTubes – Captioning the Internet! CRISPR-Cas3 could be the new gene editing tool we need to finally eliminate diseases from our genome. Here’s how it works.
What Happens When a Human Gets Rabies? – https://youtu.be/0PHoioJ2ViY
CRISPR-Cas3 innovation holds promise for disease cures, advancing science
“The CRISPR-Cas3 technology also allows researchers to scan through the genome and detect non-coding genetic elements, which make up 98 percent of our genome but have not been well characterized. These elements act as regulators that control the expression of proteins in coding genes, and they’ve been found to be pivotal for cell differentiation and sex determination. CRISPR-Cas3 could be used to efficiently screen for non-coding genetic elements and erase long sequences of DNA. Once erased, researchers may look to see what functions are missing in an organism, to determine the role of that genetic element.”
CRISPR gene editing produces unwanted DNA deletions
“CRISPR -Cas9 gene editing relies on the Cas9 enzyme to cut DNA at a particular target site. The cell then attempts to reseal this break using DNA repair mechanisms. These mechanisms do not always work perfectly, and sometimes segments of DNA will be deleted or rearranged, or unrelated bits of DNA will become incorporated into the chromosome.”
New DNA “shredder” technique goes beyond CRISPR’s scissors
“The new tool uses a Type I CRISPR, which is much more common in bacteria than the Type II variety that includes Cas9. Type I CRISPR has never been used in any eukaryotic cells, and employs a riboprotein complex known as Cascade for seeking its target and an enzyme called Cas3 for shredding DNA. The challenging protein optimization and purification side of the work was done in the laboratory of Cornell University professor Ailong Ke, Ph.D., a co-corresponding author of the paper. Cornell graduate student Adam Dolan and U-M senior research specialist Zhonggang Hou, Ph.D. are the paper’s first authors.”
Elements is more than just a science show. It’s your science-loving best friend, tasked with keeping you updated and interested on all the compelling, innovative and groundbreaking science happening all around us. Join our passionate hosts as they help break down and present fascinating science, from quarks to quantum theory and beyond.
Seeker explains every aspect of our world through a lens of science, inspiring a new generation of curious minds who want to know how today’s discoveries in science, math, engineering and technology are impacting our lives, and shaping our future. Our stories parse meaning from the noise in a world of rapidly changing information.
Visit the Seeker website https://www.seeker.com/videos
Elements on Facebook https://www.facebook.com/SeekerElements/
Subscribe now! http://www.youtube.com/subscription_center?add_user=dnewschannel
Seeker on Twitter http://twitter.com/seeker
Seeker on Facebook https://www.facebook.com/SeekerMedia/